This session will highlight IHC’s critical evolution from a cornerstone diagnostic technique to an indispensable predictive tool driving precision medicine. Gain practical insights into diverse antibody types, their optimal applications, inherent limitations, and the critical considerations for ensuring robust clinical validation and interpretation in contemporary pathology practice, and peer into the horizon of IHC, exploring how emerging AI-powered quantitative scoring methods, new algorithms like QSC, are set to redefine diagnostic precision and predictive power.